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Title: Emerging liver-kidney interactions in non-alcoholic fatty liver disease.
Authors: Cohney, Solomon (Shlomo)
Other Authors: Musso, Giovanni
Cassader, Maurizio
Pinach, S.
Saba, F.
Gambino, Roberto
Keywords: UroRenal, Vascular Clinical Institute, Epworth HealthCare, Victoria, Australia
Department of Nephrology, Epworth HealthCare, Richmond, Victoria, Australia
Department of Gastroenterology, Epworth HealthCare, Richmond, Victoria, Australia
Non-alcoholic Fatty Liver Disease
Fatty Liver, Nonalcoholic
Renal Insufficiency, Chronic
Kidney Insufficiency, Chronic
Chronic Kidney Diseases
EGFR protein, human
ACE2 enzyme
Angiotensin Converting Enzyme
AMP-Activated Protein Kinases
Fibroblast growth factor 21
Insulin-Like Growth Factor I
Issue Date: Oct-2015
Publisher: Elsevier
Citation: Trends in Moledular Medicine. 2015 Oct;21(10):645-62.
Abstract: Mounting evidence connects non-alcoholic fatty liver disease (NAFLD) to chronic kidney disease (CKD). We review emerging mechanistic links between NAFLD and CKD, including altered activation of angiotensin converting enzyme (ACE)-2, nutrient/energy sensors sirtuin-1 and AMP-activated kinase, as well as impaired antioxidant defense mediated by nuclear factor erythroid 2-related factor-2 (Nrf2). Dietary fructose excess may also contribute to NAFLD and CKD. NAFLD affects renal injury through lipoprotein dysmetabolism and altered secretion of the hepatokines fibroblast growth factor-21, fetuin-A, insulin-like growth factor-1, and syndecan-1. CKD may mutually aggravate NAFLD and associated metabolic disturbances through altered intestinal barrier function and microbiota composition, the accumulation of uremic toxic metabolites, and alterations in pre-receptor glucocorticoid metabolism. We conclude by discussing the implications of these findings for the treatment of NAFLD and CKD.
DOI: 10.1016/j.molmed.2015.08.005
PubMed URL:
ISSN: 1471-4914
Journal Title: Trends in Moledular Medicine.
Type: Journal Article
Affiliated Organisations: Gradenigo Hospital, University of Turin, Turin, Italy.
Department of Medical Sciences, San Giovanni Battista Hospital, University of Turin, Turin, Italy.
Department of Nephrology, Royal Melbourne Hospital, Parville, Victoria, Australia.
Department of Nephrology, Western Hospital, Sunshine/Footscray, Victoria, Australia.
The University of Melbourne, Parkville, Victoria, Australia.
Type of Clinical Study or Trial: Review
Appears in Collections:General Surgery and Gastroenterology
UroRenal, Vascular

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