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|Title:||Emerging liver-kidney interactions in non-alcoholic fatty liver disease.|
|Epworth Authors:||Cohney, Solomon (Shlomo)|
|Other Authors:||Musso, Giovanni|
|Keywords:||UroRenal, Vascular Clinical Institute, Epworth HealthCare, Victoria, Australia|
Department of Nephrology, Epworth HealthCare, Richmond, Victoria, Australia
Department of Gastroenterology, Epworth HealthCare, Richmond, Victoria, Australia
Non-alcoholic Fatty Liver Disease
Fatty Liver, Nonalcoholic
Renal Insufficiency, Chronic
Kidney Insufficiency, Chronic
Chronic Kidney Diseases
EGFR protein, human
Angiotensin Converting Enzyme
AMP-Activated Protein Kinases
Fibroblast growth factor 21
Insulin-Like Growth Factor I
|Citation:||Trends in Moledular Medicine. 2015 Oct;21(10):645-62.|
|Abstract:||Mounting evidence connects non-alcoholic fatty liver disease (NAFLD) to chronic kidney disease (CKD). We review emerging mechanistic links between NAFLD and CKD, including altered activation of angiotensin converting enzyme (ACE)-2, nutrient/energy sensors sirtuin-1 and AMP-activated kinase, as well as impaired antioxidant defense mediated by nuclear factor erythroid 2-related factor-2 (Nrf2). Dietary fructose excess may also contribute to NAFLD and CKD. NAFLD affects renal injury through lipoprotein dysmetabolism and altered secretion of the hepatokines fibroblast growth factor-21, fetuin-A, insulin-like growth factor-1, and syndecan-1. CKD may mutually aggravate NAFLD and associated metabolic disturbances through altered intestinal barrier function and microbiota composition, the accumulation of uremic toxic metabolites, and alterations in pre-receptor glucocorticoid metabolism. We conclude by discussing the implications of these findings for the treatment of NAFLD and CKD.|
|Journal Title:||Trends in Moledular Medicine.|
|Affiliated Organisations:||Gradenigo Hospital, University of Turin, Turin, Italy.|
Department of Medical Sciences, San Giovanni Battista Hospital, University of Turin, Turin, Italy.
Department of Nephrology, Royal Melbourne Hospital, Parville, Victoria, Australia.
Department of Nephrology, Western Hospital, Sunshine/Footscray, Victoria, Australia.
The University of Melbourne, Parkville, Victoria, Australia.
|Type of Clinical Study or Trial:||Review|
|Appears in Collections:||UroRenal, Vascular|
General Surgery and Gastroenterology
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