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|Title:||The arrector pili muscle, the bridge between the follicular stem cell niche and the interfollicular epidermis.|
|Epworth Authors:||Sinclair, Rodney|
|Keywords:||Arrector Pili Muscle|
Dermatology Research Centre, Epworth HealthCare
Chair of Dermatology, Epworth HealthCare
Head & Neck Clinical Institute, Epworth HealthCare, Victoria, Australia
|Citation:||Anat Sci Int. 2017 Jan;92(1):151-158. Epub 2016 Jul 29.|
|Abstract:||Proximally, the arrector pili muscle (APM) attaches to the follicular stem cell niche in the bulge, but its distal properties are comparatively unclear. In this work, a novel method employing an F-actin probe, phalloidin, was employed to visualize the APM anatomy. Phalloidin staining of the APM was validated by comparison with conventional antibodies/stains and by generating three-dimensional reconstructions. The proximal attachment of the APM to the bulge in 8 patients with androgenic alopecia was studied using Masson's trichrome stain. Phalloidin visualized extensive branching of the APM. The distal end of the human APM exhibits a unique "C"-shaped structure connecting to the dermal-epidermal junction. The proximal APM attachment was observed to be lost or extremely miniaturized in androgenic alopecia. The unique shape, location, and attachment sites of the APM suggest a significant role for this muscle in maintaining follicular integrity. Proximally, the APM encircles the follicular unit and only attaches to the primary hair follicle in the bulge; this attachment is lost in irreversible hair loss. The APM exhibits an arborized morphology as it ascends toward the epidermis, and anchors to the basement membrane.|
|Journal Title:||Anatomical Science International|
|Affiliated Organisations:||Department of Dermatology, School of Medicine and Dentistry, University of Melbourne, Australia.|
|Type of Clinical Study or Trial:||Comparative Study|
|Appears in Collections:||Head & Neck|
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