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Title: Alopecia areata bulbs show significant transcriptional abnormalities before, during and after active hair loss.
Epworth Authors: Li, Jane
Rufaut, Nicholas
Jones, Leslie
Sinclair, Rodney
Other Authors: van Vliet, C.
Carbone, Francis
Keywords: Department of Dermatology, Epworth HealthCare, Richmond, Victoria, Australia.
Head & Neck Clinical Institute, Epworth HealthCare, Victoria, Australia
Alopecia Areata
Hair Follicle
Laser Capture Microdissection
Messenger RNA
Gene Expression
Polymerase Chain Reaction
Issue Date: Jul-2016
Conference: Epworth Research Institute Research Week 2016.
Conference Location: Epworth HealthCare, Richmond, Victoria, Australia.
Abstract: Alopecia areata (AA) is a common relapsing, remitting hair loss disorder of unknown aetiology. Hair follicle bulbs in the anagen growth phase are the primary site of autoimmune attack. Indeed, the histological hallmark of AA is a T cell infiltrate surrounding the anagen hair bulb resembling a "swarm of bees". However, previous studies of gene expression in AA have mainly examined patient serum or bulk tissue rather than targeting the hair bulb.
Type: Conference Poster
Affiliated Organisations: Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
Department of Medicine [St Vincent's Hospital], The University of Melbourne, Fitzroy, Victoria, Australia.
Type of Clinical Study or Trial: Comparative Study
Appears in Collections:Head & Neck

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