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dc.contributor.authorChan, Miranda-
dc.contributor.authorTjandra, Joe-
dc.identifier.citationDis Colon Rectum. 2008 Jul;51(7):1015-24; discussion 1024-5en_US
dc.description.abstractPURPOSE: This prospective study was designed to assess the effectiveness of sacral nerve stimulation for fecal incontinence in patients with external anal sphincter defect and to evaluate its efficacy regarding presence and size of sphincter defect. METHODS: Fifty-three consecutive patients who underwent sacral nerve stimulation for fecal incontinence were divided into two groups: external anal sphincter defect group (n = 21) vs. intact sphincter group (n = 32). Follow-up was performed at 3, 6, and 12 months with anorectal physiology, Wexner's score, bowel diary, and quality of life questionnaires. RESULTS: The external anal sphincter defect group (defect <90 degrees:defect 90 degrees-120 degrees = 11:10) and intact sphincter group were comparable with regard to age (mean, 63 vs. 63.6) and sex. Incidence of internal anal sphincter defect and pudendal neuropathy was similar. All 53 patients benefited from sacral nerve stimulation. Weekly incontinent episodes decreased from 13.8 to 5 (P < 0.0001) for patients with external anal sphincter defects and from 6.7 to 2 (P = 0.001) for patients with intact sphincter at 12-month follow-up. Quality of life scores improved in both groups (P < 0.0125). There was no significant difference in improvement in functional outcomes after sacral nerve stimulation between patients with or without external anal sphincter defects. Clinical benefit of sacral nerve stimulation was similar among patients with external anal sphincter defects, irrespective of its size. Presence of pudendal neuropathy did not affect outcome of neurostimulation. CONCLUSIONS: Sacral nerve stimulation for fecal incontinence is as effective in patients with external anal sphincter defects as those with intact sphincter and the result is similar for defect size up to 120 degrees of circumference.en_US
dc.publisherSpringer Verlagen_US
dc.subjectFecal Incontinenceen_US
dc.subjectLumbosacral Plexusen_US
dc.subjectElectric Stimulation Therapyen_US
dc.subjectAnorectal Physiologyen_US
dc.subjectWexner's Scoreen_US
dc.subjectExternal Anal Sphincter Defecten_US
dc.subjectSacral Nerve Stimulationen_US
dc.subjectDepartment of Colorectal Surgery, Epworth Hospital, Melbourne, Australiaen_US
dc.subjectGeneral Surgery and Gastroenterology Clinical Institute, Epworth HealthCare, Victoria, Australiaen_US
dc.titleSacral nerve stimulation for fecal incontinence: external anal sphincter defect vs. intact anal sphincter.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleDiseases of the Colon and Rectumen_US
dc.description.affiliatesUniversity of Melbourne, Melbourne, Australiaen_US
dc.type.studyortrialProspective Studyen_US
Appears in Collections:General Surgery and Gastroenterology
UroRenal, Vascular

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