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Title: Cytoreductive surgery for men with metastatic prostate cancer.
Authors: Murphy, Declan
Lawrentschuk, Nathan
Moon, Daniel
Other Authors: Katelaris, Nikolas
Katelaris, Athos
Keywords: Cytoreduction
Prostatic Neoplasms
Metastatic Prostate Cancer
Radical Prostatectomy
Australian Prostate Cancer Centre, Epworth Healthcare, Melbourne, Australia
UroRenal, Vascular Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: 2016
Publisher: Elsevier
Abstract: Background. Cytoreductive surgery for metastatic prostate cancer is an emerging area of interest with a potential upside that includes local control, delayed initiation of hormone therapy, and possibly improved cancer specific survival. In order for radical prostatectomy to be an effective treatment option for men in this group, the benefits must outweigh the surgical morbidity. The aim of this study was to present a case series and assess the literature feasibility of cytoreductive surgery for men with metastatic prostate cancer. Methods. The case series (n = 6) evaluated each patient with regard to preoperative prostate-specific antigen, grade, stage, adjuvant therapy, and surgical outcomes. A full literature review of cytoreductive radical prostatectomy was undertaken. Results. A surgical approach had demonstrated benefit without deleterious effect in these case. Notably, in the three men on ADT pre-operatively, the PSA remained lower after aggressive treatment of local and metastatic disease, and at follow-up, none of the men had local symptoms from malignancy or the surgery. Conclusions. This case series supports recent data demonstrating that radical prostatectomy for carefully selected men is feasible. There is a need for further studies to explore the role of cytoreductive surgery in men with oligometastatic prostate cancer.
DOI: doi:10.1016/j.prnil.2015.11.003
ISSN: 2287-8882
Journal Title: Prostate International
Type: Journal Article
Affiliated Organisations: University of Melbourne, Department of Surgery, Austin Hospital, Melbourne, Australia
University of Melbourne, Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Australia
Olivia Newton-John Cancer Research Institute, Austin Hospital, Melbourne, Australia
St. Georges, University of London, London, United Kingdom
Type of Clinical Study or Trial: Case Series and Case Reports
Appears in Collections:Cancer Services
Epworth Prostate Centre
UroRenal, Vascular

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