Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/688
Title: Brain lesion correlates of fatigue in individuals with traumatic brain injury.
Epworth Authors: Ponsford, Jennie
O'Sullivan, Richard
Schonberger, Michael
Other Authors: Reutens, D.
Beare, R.
Rajaratnam, S. M.
Keywords: Monash-Epworth Rehabilitation Research Centre, Epworth Hospital, Melbourne, Victoria, Australia.
Symbion Imaging, Epworth Hospital, Melbourne, Victoria, Australia.
Rehabilitation, Mental Health and Chronic Pain Clinical Institute, Epworth HealthCare, Victoria, Australia
Brain Injuries
TBI
Injury, Brain, Traumatic
Trauma, Brain
Traumatic Brain Injury
Fatigue
Magnetic Resonance Imaging
MRI Scans
Grey Matter
White Matter
Lesions
Issue Date: Mar-2016
Publisher: Taylor & Francis
Citation: Neuropsychological Rehabilitation. 2016 Mar 9:1-15.
Abstract: The purpose of this study was to investigate the neurological correlates of both subjective fatigue as well as objective fatigability in individuals with traumatic brain injury (TBI). The study has a cross-sectional design. Participants (N = 53) with TBI (77% male, mean age at injury 38 years, mean time since injury 1.8 years) underwent a structural magnetic resonance imaging (MRI) scan and completed the Fatigue Severity Scale (FSS), while a subsample (N = 36) was also tested with a vigilance task. While subjective fatigue (FSS) was not related to measures of brain lesions, multilevel analyses showed that a change in the participants' decision time was significantly predicted by grey matter (GM) lesions in the right frontal lobe. The time-dependent development of the participants' error rate was predicted by total brain white matter (WM) lesion volumes, as well as right temporal GM and WM lesion volumes. These findings could be explained by decreased functional connectivity of attentional networks, which results in accelerated exhaustion during cognitive task performance. The disparate nature of objectively measurable fatigability on the one hand and the subjective experience of fatigue on the other needs further investigation.
URI: http://hdl.handle.net/11434/688
DOI: 10.1080/09602011.2016.1154875
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/26957190
ISSN: 0960-2011
1464-0694
Journal Title: Neuropsychological Rehabilitation
Type: Journal Article
Affiliated Organisations: Department of Rehabilitation Psychology, Institute of Psychology, University of Freiburg , Freiburg , Germany.
School of Psychological Sciences, Monash University Melbourne, Melbourne, Victoria, Australia.
Department of Medicine, Monash Medical Centre, Monash University Melbourne, Melbourne, Victoria, Australia.
Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland, Australia.
Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.
National Trauma Research Institute, Melbourne, Victoria, Australia.
Type of Clinical Study or Trial: Cross-Sectional Study
Appears in Collections:Neurosciences
Rehabilitation
Mental Health
Diagnostic Services

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