Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/660
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dc.contributor.authorKing, Bronwyn-
dc.contributor.otherGaffney, David-
dc.contributor.otherViswanathan, Akila-
dc.contributor.otherBarkati, Maroie-
dc.contributor.otherBeriwal, Susil-
dc.contributor.otherEifel, Patricia-
dc.contributor.otherErickson, Beth-
dc.contributor.otherFyles, Anthony-
dc.contributor.otherGoulart, Jennifer-
dc.contributor.otherHarkenrider, Matthew-
dc.contributor.otherJhingran, Anuja-
dc.contributor.otherKlopp, Ann-
dc.contributor.otherKoh, Wui-Jin-
dc.contributor.otherLim, Karen-
dc.contributor.otherPetersen, Ivy-
dc.contributor.otherPortelance, Lorraine-
dc.contributor.otherSmall, William-
dc.contributor.otherStewart, Alexandra-
dc.contributor.otherWiebe, Ericka-
dc.contributor.otherWolfson, Aaron-
dc.contributor.otherYashar, Catheryn-
dc.contributor.otherBosch, Walter-
dc.date2016-02-21-
dc.date.accessioned2016-05-13T04:39:50Z-
dc.date.available2016-05-13T04:39:50Z-
dc.date.issued2016-02-
dc.identifier.citationInt J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1191-200en_US
dc.identifier.issn0360-3016en_US
dc.identifier.urihttp://hdl.handle.net/11434/660-
dc.description.abstractPURPOSE: The purpose of this study was to develop a radiation therapy (RT) contouring atlas and recommendations for women with postoperative and locally advanced vulvar carcinoma. METHODS AND MATERIALS: An international committee of 35 expert gynecologic radiation oncologists completed a survey of the treatment of vulvar carcinoma. An initial set of recommendations for contouring was discussed and generated by consensus. Two cases, 1 locally advanced and 1 postoperative, were contoured by 14 physicians. Contours were compared and analyzed using an expectation-maximization algorithm for simultaneous truth and performance level estimation (STAPLE), and a 95% confidence interval contour was developed. The level of agreement among contours was assessed using a kappa statistic. STAPLE contours underwent full committee editing to generate the final atlas consensus contours. RESULTS: Analysis of the 14 contours showed substantial agreement, with kappa statistics of 0.69 and 0.64 for cases 1 and 2, respectively. There was high specificity for both cases (≥99%) and only moderate sensitivity of 71.3% and 64.9% for cases 1 and 2, respectively. Expert review and discussion generated consensus recommendations for contouring target volumes and treatment for postoperative and locally advanced vulvar cancer. CONCLUSIONS: These consensus recommendations for contouring and treatment of vulvar cancer identified areas of complexity and controversy. Given the lack of clinical research evidence in vulvar cancer radiation therapy, the committee advocates a conservative and consistent approach using standardized recommendations.en_US
dc.publisherElsevieren_US
dc.subjectVulvar Carcinomaen_US
dc.subjectVulvar Canceren_US
dc.subjectRadiation Therapyen_US
dc.subjectRadiation Oncologyen_US
dc.subjectContouring Atlasen_US
dc.subjectLocally Advanceden_US
dc.subjectPostoperativeen_US
dc.subjectSimultaneous Truth and Performance Level Estimationen_US
dc.subjectSTAPLEen_US
dc.subjectExpectation-Maximization Algorithmen_US
dc.subjectKappaen_US
dc.subjectEpworth Radiation Oncology Research Centreen_US
dc.subjectObstetrics and Gynaecology Clinical Institute, Epworth HealthCare, Victoria, Australia-
dc.subjectCancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia-
dc.titleConsensus recommendations for radiation therapy contouring and treatment of vulvar carcinoma.en_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/j.ijrobp.2016.02.043en_US
dc.identifier.journaltitleInternational Journal of Radiation Oncology*Biology*Physicsen_US
dc.description.pubmedurihttp://www.ncbi.nlm.nih.gov/pubmed/27130794en_US
dc.description.affiliatesDepartment of Radiation Oncology, Huntsman Cancer Hospital, Salt Lake City, Utah, USAen_US
dc.description.affiliatesDepartment of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USAen_US
dc.description.affiliatesDepartment of Radiation Oncology, Centre hospitalier de l'universite de Montreal, Montreal, Quebec, Canadaen_US
dc.description.affiliatesDepartment of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USAen_US
dc.description.affiliatesDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas, USAen_US
dc.description.affiliatesDepartment of Radiation Oncology, Proedtert and Medical College Clinical Cancer Center, Milwaukee, Wisconsin, USAen_US
dc.description.affiliatesDepartment of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canadaen_US
dc.description.affiliatesDepartment of Radiation Oncology, British Columbia Cancer Agency, Victoria, British Columbia, Canadaen_US
dc.description.affiliatesDepartment of Radiation Oncology, Stritch School of Medicine, Loyola University, Maywood, Illinois, USAen_US
dc.description.affiliatesDepartment of Radiation Oncology, University of Washington, Seattle, Washington, USAen_US
dc.description.affiliatesLiverpool Cancer Therapy Centre, Radiation Oncology Unit, Sydney, New South Wales, Australiaen_US
dc.description.affiliatesDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USAen_US
dc.description.affiliatesRadiation Oncology Department, Miller School of Medicine, University of Miami, Miami, Florida, USAen_US
dc.description.affiliatesSt. Luke's Cancer Centre, Royal Surrey Country Hospital, Surrey, United Kingdomen_US
dc.description.affiliatesDepartment of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canadaen_US
dc.description.affiliatesRadiation Medicine and Applied Sciences, University of California San Diego, San Diego, California, USAen_US
dc.description.affiliatesDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USAen_US
dc.description.affiliatesDepartment of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centreen_US
dc.type.studyortrialRealist Reviews in Medicineen_US
dc.type.contenttypeTexten_US
Appears in Collections:Cancer Services
Obstetrics & Gynaecology
Radiation Oncology

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