Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/657
Title: Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height - a 3.0 T-MRI study.
Epworth Authors: Sullivan, Richard
Other Authors: Teichtahl, Andrew
Urquhart, Donna
Wang, Yuanyuan
Wluka, Anita
Jones, Graeme
Cicuttini, Flavia
Keywords: Vertebral Endplate Abnormalities
Modic Change
Lumbar Spine
Structural Lesions
Intervertebral Disc
Body Composition
Fat Distribution
Fat Mass
Fat Free Mass
Android Fat
Gynoid Fat
Inervertebral Disc Height
Adiposity
Magnetic Resonance Imaging
MRI
Obesity
Musculoskeletal Health
Healthcare Imaging Services, Epworth Hospital, Richmond, Melbourne, VIC
Issue Date: Feb-2016
Publisher: Bio Med Central
Citation: BMC Musculoskeletal Disorders
Abstract: BACKGROUND: Vertebral endplate (Modic) abnormalities are important structural lesions in the spine, but their association with body composition and fat distribution have not been examined. Moreover, no study has examined whether Modic change are related to other structural features of low back pain, such as reduced intervertebral disc height. Methods: Seventy-two community-based individuals not selected for low back pain had lumbar vertebral Modic change and intervertebral disc height assessed from MRI. Dual energy x-ray absorptiometry measured body composition and fat distribution. Results: The predominance of Modic change was type 2. Modic change was associated with an increased fat mass index (OR 1.20, 95 % CI 1.01 to 1.43), and tended to be associated with a reduced fat-free mass index (OR 0.62, 95 % CI 0.37 to 1.03, p = 0.07). While an increased percentage of gynoid fat was associated with a reduced risk (OR 0.62, 95 % CI 0.43 to 0.89), an increased percentage of android fat was associated with an increased risk of Modic change (OR 2.11, 95 % CI 1.18 to 3.76). Modic change was also associated with reduced intervertebral disc height at L2/3, L4/5 and L5/S1 (OR range 1.4 to 1.8; all p ≤ 0.03). Conclusion: Modic type 2 change is associated with reduced intervertebral disc height and an increased fat mass index. Whereas gynoid fat distribution protected against Modic type 2 change, an android pattern increased the risk of this lesion. Modic type 2 change, which histologically represent fat replacement, might have a metabolic component to its aetiology.
URI: http://hdl.handle.net/11434/657
DOI: doi: 10.1186/s12891-016-0934-x.
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759726/pdf/12891_2016_Article_934.pdf
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/26891686
ISSN: 1471-2474
Journal Title: BMC Musculoskelet Disord. 2016 Feb 19;17(1):92.
Type: Journal Article
Affiliated Organisations: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia
Baker IDI Heart and Diabetes Institute, Commercial Road, Melbourne, VIC, 3004, Australia.
Type of Clinical Study or Trial: Cohort Study
Appears in Collections:Diagnostic Services
Musculoskeletal

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