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Title: Androgenetic alopecia: pathogenesis and potential for therapy.
Epworth Authors: Sinclair, Rodney
Other Authors: Ellis, J.
Harrap, Stephen
Keywords: Alopecia
Androgenetic Alopecia
Hair Follicle
Department of Dermatology, Epworth HealthCare, Victoria, Australia
Head & Neck Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Nov-2002
Publisher: Cambridge
Citation: Expert Rev Mol Med. 2002 Nov 19;4(22):1-11
Abstract: Androgenetic alopecia occurs in men and women, and is characterised by the loss of hair from the scalp in a defined pattern. Determining factors appear to be genetic predisposition coupled with the presence of sufficient circulating androgens. The prevalence of this condition is high (up to 50% of white males are affected by 50 years of age) and, although there are no serious direct health consequences, the loss of scalp hair can be distressing. Knowledge of the pathogenesis of androgenetic alopecia has increased markedly in recent years. Pre-programmed follicles on the scalp undergo a transformation from long growth (anagen) and short rest (telogen) cycles, to long rest and short growth cycles. This process is coupled with progressive miniaturisation of the follicle. These changes are androgen dependent, and require the inheritance of several genes. To date, only one of these genes, which encodes the androgen receptor (AR), has been identified. Of the many treatments available for androgenetic alopecia, only two (finasteride and minoxidil) have been scientifically shown to be useful in the treatment of hair loss. However, these therapies are variable in their effectiveness. Discovery of the involvement of the AR gene, and the identification of other genes contributing to the condition, might lead to the development of new and more effective therapies that target the condition at a more fundamental level.
PubMed URL:
ISSN: 1462-3994
Journal Title: Expert reviews in molecular medicine
Type: Journal Article
Affiliated Organisations: Department of Physiology, The University of Melbourne, Victoria 3010, Australia
Type of Clinical Study or Trial: Review
Appears in Collections:Head & Neck

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