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Title: Use of spironolactone in dermatology.
Epworth Authors: Sinclair, Rodney
Other Authors: Rathnayake, D.
Keywords: Alopecia
Hair Loss
Acne Vulgaris
Mineralocorticoid Receptor Anatagonists
Female Pattern Hair Loss
Drug Therapy
Chair of Dermatology, Epworth HealthCare, Victoria, Australia
Head & Neck Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Nov-2010
Publisher: Wiley
Citation: Skinmed. 2010 Nov-Dec;8(6):328-32; quiz 333.
Abstract: Spironolactone has been used as a potassium-sparing diuretic for more than 30 years. It is a synthetic 17-lactone steroid and primarily acts as an aldosterone antagonist. Since the accidental discovery of its antiandrogenic effects, it has been used in the treatment of many dermatologic conditions in which androgen plays a role in the pathogenesis. Antiandrogenic effects of spironolactone are exerted by reducing testosterone production and inhibiting its action on the target tissues. Spironolactone is used as a primary medical treatment for hirsutism and female pattern hair loss. Continuous treatment is required to sustain the effect. It is an effective alternative treatment for acne in women. It has the benefit of a long-term safety profile. Spironolactone should not be used in pregnancy due to its teratogenic effects and is not used in men due to the risk of feminization.
PubMed URL:
ISSN: 1751-7125
Journal Title: SKINmed: Dermatology for the Clinician
Type: Journal Article
Affiliated Organisations: Department of Dermatology, St Vincent's Hospital, Melbourne, Victoria, Australia
Type of Clinical Study or Trial: Review
Appears in Collections:Head & Neck

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