Please use this identifier to cite or link to this item:
|Title:||Prospective assessment of the false positive rate of the Australian Snake Venom Detection Kit in healthy human samples.|
|Epworth Authors:||Nimorakiotakis, V (Bill)|
|Other Authors:||Winkel, K|
|Keywords:||Emergency Department, Epworth Hospital, 89 Bridge Road, Richmond, Victoria, Australia.|
Snake Venom Detection Kit
|Citation:||Toxicon. 2015 Dec 12. pii: S0041-0101(15)30145-8.|
|Abstract:||The Snake Venom Detection Kit (SVDK; bioCSL Pty Ltd, Australia) distinguishes venom from the five most medically significant snake immunotypes found in Australia. This study assesses the rate of false positives that, by definition, refers to a positive assay finding in a sample from someone who has not been bitten by a venomous snake. Control unbroken skin swabs, simulated bite swabs and urine specimens were collected from 61 healthy adult volunteers [33 males and 28 females] for assessment. In all controls, simulated bite site and urine samples [a total of 183 tests], the positive control well reacted strongly within one minute and no test wells reacted during the ten minute incubation period. However, in two urine tests, the negative control well gave a positive reaction (indicating an uninterpretable test). A 95% confidence interval for the false positive rate, on a per-patient rate, derived from the findings of this study, would extend from 0% to 6% and, on a per-test basis, it would be 0 to 2%. It appears to be a very low incidence (0-6%) of intrinsic true false positives for the SVDK. The clinical impresssion of a high SVDK false positive rate may be mostly related to operator error.|
|Affiliated Organisations:||Sunshine Hospital, St Albans, Victoria, Australia.|
Retrieval Services Queensland, Robina, Queensland, Australia.
Australian Venom Research Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Victoria, Australia.
|Type of Clinical Study or Trial:||Prospective Study|
|Appears in Collections:||Emergency Care|
Files in This Item:
There are no files associated with this item.
Items in EKB are protected by copyright, with all rights reserved, unless otherwise indicated.