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Title: Computational simulation of the early stage of bone healing under different configurations of locking compression plates.
Epworth Authors: Richardson, Martin
Other Authors: Miramini, Saeed
Zhang, Lihai
Pirpiris, Marinis
Mendis, Priyan
Oloyede, Kunle
Edwards, Glenn
Keywords: Bones and Bone Tissue
Fracture Healing
Bone Remodeling
Fracture Fixation
Bone Formation
Bone Plates
Cell Microenvironment
Musculoskeletal Clinical Institute, Epworth HealthCare, Victoria, Australia
Department of Orthopaedics, Epworth HealthCare, Melbourne, Victoria, Australia.
Issue Date: Aug-2015
Publisher: Taylor & Francis Online
Citation: Computer Methods in Biomechanics and Biomedical Engineering 2015;18(8):900-13.
Abstract: Flexible fixation or the so-called 'biological fixation' has been shown to encourage the formation of fracture callus, leading to better healing outcomes. However, the nature of the relationship between the degree of mechanical stability provided by a flexible fixation and the optimal healing outcomes has not been fully understood. In this study, we have developed a validated quantitative model to predict how cells in fracture callus might respond to change in their mechanical microenvironment due to different configurations of locking compression plate (LCP) in clinical practice, particularly in the early stage of healing. The model predicts that increasing flexibility of the LCP by changing the bone-plate distance (BPD) or the plate working length (WL) could enhance interfragmentary strain in the presence of a relatively large gap size (> 3 mm). Furthermore, conventional LCP normally results in asymmetric tissue development during early stage of callus formation, and the increase of BPD or WL is insufficient to alleviate this problem.
DOI: 10.1080/10255842.2013.855729
PubMed URL:
ISSN: 1025-5842
Journal Title: Computer Methods in Biomechanics and Biomedical Engineering
Type: Journal Article
Affiliated Organisations: Department of Infrastructure Engineering , The University of Melbourne , Melbourne, Victoria, Australia.
Type of Clinical Study or Trial: Validation Study
Appears in Collections:Musculoskeletal

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