Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/471
Title: The proteomic profile of hair damage.
Epworth Authors: Sinclair, Rodney
Rufaut, Nick
Jones, Leslie
Other Authors: Flagler, M.
Davis, M.
Keywords: Hair
Electrophoresis
Keratins
Metabolism
Monilethrix
Hair Shaft Disorder
Hair Strength
Cosmetic Insult
Mass Spectometry
Oxidative Stress
Proteomics
Hair Preparations
Hair Weathering
Chair of Dermatology, Epworth HealthCare
Head & Neck Clinical Institute, Epworth HealthCare
Issue Date: Jun-2012
Publisher: Wiley
Citation: Br J Dermatol. 2012 Jun;166 Suppl 2:27-32
Abstract: BACKGROUND: Monilethrix is a congenital hair shaft disorder with associated fragility. Many of the changes seen in monilethrix hair on light microscopy and scanning electron microscopy are also seen in hair weathering and cosmetic damage to hair. OBJECTIVES: We used monilethrix as a model to investigate the relationship between hair protein structure and hair strength and resistance to cosmetic insult. METHODS: We applied proteomic techniques to identify novel peptide damage markers for chemical oxidative damage to hair. RESULTS: The findings suggest that specific sites in the protein structure of hair are targeted during oxidative damage from bleaching, a unique insight into how chemical damage compromises the structural integrity of the hair shaft at the molecular level. CONCLUSIONS: Applying proteomics to the study of congenital and acquired hair shaft disorders can deliver new insights into hair damage and novel strategies to strengthen hair
URI: http://hdl.handle.net/11434/471
DOI: 10.1111/j.1365-2133.2012.10862.x.
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/22670616
ISSN: 1365-2133
Journal Title: British Journal of Dermatology
Type: Journal Article
Affiliated Organisations: University of Melbourne, Victoria, Australia
Type of Clinical Study or Trial: Cohort Study
Appears in Collections:Head & Neck
Dermatology

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