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http://hdl.handle.net/11434/406
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DC Field | Value | Language |
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dc.contributor.author | Hovens, Christopher | - |
dc.contributor.author | Harewood, Laurence | - |
dc.contributor.author | Peters, Justin | - |
dc.contributor.author | Costello, Anthony | - |
dc.contributor.author | Corcoran, Niall | - |
dc.contributor.other | Reeves, Fairleigh | - |
dc.contributor.other | Battye, Shane | - |
dc.date.accessioned | 2015-10-07T03:06:08Z | - |
dc.date.available | 2015-10-07T03:06:08Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | Can Urol Assoc J. 2015 May-Jun;9(5-6):E252-5 | en_US |
dc.identifier.issn | 1920-1214 | en_US |
dc.identifier.uri | http://hdl.handle.net/11434/406 | - |
dc.description.abstract | INTRODUCTION: The ability of perineural invasion (PNI) in radical prostatectomy (RP) specimens to predict biochemical recurrence (BCR) is unclear. This study investigates this controversial question in a large cohort. METHODS: A retrospective analysis was undertaken of prospectively collected data from 1497 men who underwent RP (no neoadjuvant therapy) for clinically localized prostate cancer. The association of PNI at RP with other clinicopathological parameters was evaluated. The correlation of clinicopathological factors and BCR (defined as prostate-specific antigen [PSA] >0.2 ng/mL) was investigated with univariable and multivariable Cox regression analysis in 1159 men. RESULTS: PNI-positive patients were significantly more likely to have a higher RP Gleason score, pT3 disease, positive surgical margins, and greater cancer volume (p < 0.0005). The presence of PNI significantly correlated with BCR on univariable (hazard ratio 2.30, 95% confidence interval 1.50-3.55, p < 0.0005), but not multivariable analysis (p = 0.602). On multivariable Cox regression analysis the only independent prognostic factors were preoperative PSA, RP Gleason score, pT-stage, and positive surgical margin status. These findings are limited by a relatively short follow-up time and retrospective study design. CONCLUSIONS: PNI at RP is not an independent predictor of BCR. Therefore, routine reporting of PNI is not indicated. Future research should be targeted at the biology of PNI to increase the understanding of its role in prostate cancer progression. | en_US |
dc.publisher | PubMed Central | en_US |
dc.relation.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439219/pdf/cuaj-5-6-e252.pdf | - |
dc.subject | Australian Prostate Cancer Research Centre, Epworth HealthCare, Richmond, Australia | en_US |
dc.subject | Urorenal and Vascular | en_US |
dc.subject | Urology | en_US |
dc.subject | Prostate Cancer | en_US |
dc.subject | Perineural Invasion | en_US |
dc.subject | Radical Prostatectomy | en_US |
dc.subject | Biochemical Recurrence | en_US |
dc.subject | Clinically Localized Prostate Cancer | en_US |
dc.subject | Clinicopathological Factors | en_US |
dc.subject | Radical Prostatectomy Gleeson Score | en_US |
dc.subject | PT3 disease | en_US |
dc.subject | Positive Surgical Margins | en_US |
dc.subject | Greater Cancer Volume | en_US |
dc.subject | Men | en_US |
dc.subject | Prostatic Neoplasms | en_US |
dc.subject | Oncology | en_US |
dc.title | Does perineural invasion in a radical prostatectomy specimen predict biochemical recurrence in men with prostate cancer? | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | 10.5489/cuaj.2619 | en_US |
dc.identifier.journaltitle | Canadian Urological Association Journal | en_US |
dc.description.pubmeduri | http://www.ncbi.nlm.nih.gov/pubmed/26029290 | en_US |
dc.description.affiliates | Department of Urology and Surgery, University of Melbourne, The Royal Melbourne Hospital, Australia | en_US |
dc.description.affiliates | TissuPath Pty Ltd, Mount Waverley, Australia | en_US |
dc.type.studyortrial | Retrospective studies | en_US |
dc.type.contenttype | Text | en_US |
Appears in Collections: | Cancer Services Epworth Prostate Centre UroRenal, Vascular |
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File | Description | Size | Format | |
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11434.406.pdf | Full Text | 3.08 MB | Adobe PDF | View/Open |
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