Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/406
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dc.contributor.authorHovens, Christopher-
dc.contributor.authorHarewood, Laurence-
dc.contributor.authorPeters, Justin-
dc.contributor.authorCostello, Anthony-
dc.contributor.authorCorcoran, Niall-
dc.contributor.otherReeves, Fairleigh-
dc.contributor.otherBattye, Shane-
dc.date.accessioned2015-10-07T03:06:08Z-
dc.date.available2015-10-07T03:06:08Z-
dc.date.issued2015-05-
dc.identifier.citationCan Urol Assoc J. 2015 May-Jun;9(5-6):E252-5en_US
dc.identifier.issn1920-1214en_US
dc.identifier.urihttp://hdl.handle.net/11434/406-
dc.description.abstractINTRODUCTION: The ability of perineural invasion (PNI) in radical prostatectomy (RP) specimens to predict biochemical recurrence (BCR) is unclear. This study investigates this controversial question in a large cohort. METHODS: A retrospective analysis was undertaken of prospectively collected data from 1497 men who underwent RP (no neoadjuvant therapy) for clinically localized prostate cancer. The association of PNI at RP with other clinicopathological parameters was evaluated. The correlation of clinicopathological factors and BCR (defined as prostate-specific antigen [PSA] >0.2 ng/mL) was investigated with univariable and multivariable Cox regression analysis in 1159 men. RESULTS: PNI-positive patients were significantly more likely to have a higher RP Gleason score, pT3 disease, positive surgical margins, and greater cancer volume (p < 0.0005). The presence of PNI significantly correlated with BCR on univariable (hazard ratio 2.30, 95% confidence interval 1.50-3.55, p < 0.0005), but not multivariable analysis (p = 0.602). On multivariable Cox regression analysis the only independent prognostic factors were preoperative PSA, RP Gleason score, pT-stage, and positive surgical margin status. These findings are limited by a relatively short follow-up time and retrospective study design. CONCLUSIONS: PNI at RP is not an independent predictor of BCR. Therefore, routine reporting of PNI is not indicated. Future research should be targeted at the biology of PNI to increase the understanding of its role in prostate cancer progression.en_US
dc.publisherPubMed Centralen_US
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439219/pdf/cuaj-5-6-e252.pdf-
dc.subjectAustralian Prostate Cancer Research Centre, Epworth HealthCare, Richmond, Australiaen_US
dc.subjectUrorenal and Vascularen_US
dc.subjectUrologyen_US
dc.subjectProstate Canceren_US
dc.subjectPerineural Invasionen_US
dc.subjectRadical Prostatectomyen_US
dc.subjectBiochemical Recurrenceen_US
dc.subjectClinically Localized Prostate Canceren_US
dc.subjectClinicopathological Factorsen_US
dc.subjectRadical Prostatectomy Gleeson Scoreen_US
dc.subjectPT3 diseaseen_US
dc.subjectPositive Surgical Marginsen_US
dc.subjectGreater Cancer Volumeen_US
dc.subjectMenen_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectOncologyen_US
dc.titleDoes perineural invasion in a radical prostatectomy specimen predict biochemical recurrence in men with prostate cancer?en_US
dc.typeJournal Articleen_US
dc.identifier.doi10.5489/cuaj.2619en_US
dc.identifier.journaltitleCanadian Urological Association Journalen_US
dc.description.pubmedurihttp://www.ncbi.nlm.nih.gov/pubmed/26029290en_US
dc.description.affiliatesDepartment of Urology and Surgery, University of Melbourne, The Royal Melbourne Hospital, Australiaen_US
dc.description.affiliatesTissuPath Pty Ltd, Mount Waverley, Australiaen_US
dc.type.studyortrialRetrospective studiesen_US
dc.type.contenttypeTexten_US
Appears in Collections:Cancer Services
Epworth Prostate Centre
UroRenal, Vascular

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