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Title: Assessing pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review.
Epworth Authors: Ryan, Jennifer
Warrier, Satish
Lynch, A. Craig
Heriot, Alexander
Keywords: Epworth Healthcare, Melbourne, Victoria, Australia
Neoadjuvant Chemoradiotherapy
Locally Advanced Rectal Cancer
Rectal Cancer
Rectal Neoplasm
Neoadjuvant Therapy
Issue Date: Oct-2015
Publisher: Wiley
Citation: Colorectal Dis. 2015 Oct;17(10):849-61
Abstract: AIM: Pathological complete response to neoadjuvant chemoradiotherapy is found in 20% of patients with rectal cancer undergoing long-course chemoradiotherapy. Some authors have suggested that these patients do not need to undergo surgery and can be managed with careful follow-up, with surgery only used in the event of clinical failure. Widespread adoption of this regimen is limited by the accuracy of methods to confirm a pathological complete response (pCR).
DOI: 10.1111/codi.13081
PubMed URL:
ISSN: 1463-1318
Journal Title: Colorectal Disease
Type: Journal Article
Affiliated Organisations: Department of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Austin Academic Centre, University of Melbourne, Melbourne, Victoria, Australia
Type of Clinical Study or Trial: Systematic Reviews
Appears in Collections:Cancer Services

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