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Title: Occupational risk factors for hip osteoarthritis are associated with early hip structural abnormalities: a 3.0 T magnetic resonance imaging study of community-based adults.
Epworth Authors: O'Sullivan, Richard
Other Authors: Teichtahl, Andrew
Smith, Sam
Wang, Yuanyuan
Wluka, Anita
Cicuttini, Flavia
Giles, Graham
Keywords: Radiographic Hip Osteoarthritis
Early Structural Hip Joint Changes
Heavy Lifting
Stair Climbing
Bone Marrow Lesions
Hip Structural Abnormalities
T-magnetic resonance imaging
MRI Department, Healthcare Imaging Services, Epworth HealthCare, Victoria, Australia
Issue Date: Jan-2015
Publisher: BioMed Central
Citation: Arthritis Res Ther. 2015 Jan 28;17
Abstract: Occupational exposure to heavy lifting and stair climbing are associated with radiographic hip osteoarthritis (OA). This study examined whether these activities are associated with early structural hip joint changes in a community-based population. Methods In total, 198 community-based people with no history of hip disease, including OA, had 3.0 T-magnetic resonance imaging (MRI) to assess hip cartilage volume, defects and bone marrow lesions (BMLs). Recall of occupational exposure to heavy lifting and stair climbing aged 18 to 30 years and in the previous 10 years were collected. A persistence score was defined as exposure at neither time point (0), at one time point (1) or at both time points (2). Results Exposure to heavy lifting when aged 18 to 30 years was associated with BMLs of the central superolateral femoroacetabular region (odds ratio (OR) 3.9, 95% confidence interval (CI) 1.6 to 9.8, P <0.01), with persistence score associated with cartilage defects in the central superolateral region of the femoral head (OR 1.6, 95% CI 1.0 to 2.5, P = 0.04). Exposure to stair climbing aged 18 to 30 years and persistence score were associated with an increased risk of cartilage defects in the central superolateral femoral head and BMLs in the central superolateral and posterior femoroacetabular regions (OR range 2.1 to 3.2, all P ≤0.03). Conclusions Occupational exposure to heavy lifting and stair climbing are associated with hip structural abnormalities. If confirmed by longitudinal data, such associations may explain how occupational activities affect the hip joint and may identify new targets for the prevention of hip OA.
DOI: 10.1186/s13075-015-0535-3
PubMed URL:
ISSN: 1478 6362
Journal Title: Arthritis Research & Therapy
Type: Journal Article
Affiliated Organisations: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Victoria, Australia
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
Department of Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia
Cancer Epidemiology Centre, Cancer Council Victoria, Australia
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, Victoria, Australia
Type of Clinical Study or Trial: Retrospective studies
Appears in Collections:Diagnostic Services

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