Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/295
Title: Repair mechanisms help glioblastoma resist treatment.
Epworth Authors: Hovens, Christopher
Other Authors: Atkins, Ryan
Ng, Wayne
Stylli, Stanley
Kaye, Andrew
Keywords: Australian Prostate Cancer Research Centre at Epworth, Richmond, VIC, Australia.
Glioblastoma Multiforme
GBM
Glial Brain Tumour
Base Excision Repair
Glioma Resistance
MGMT
PARP
Temozolomide Chemotherapy
Issue Date: Jan-2015
Publisher: Elsevier
Citation: J Clin Neurosci. 2015 Jan;22(1):14-20
Abstract: Glioblastoma multiforme (GBM) is a malignant and incurable glial brain tumour. The current best treatment for GBM includes maximal safe surgical resection followed by concomitant radiotherapy and adjuvant temozolomide. Despite this, median survival is still only 14-16 months. Mechanisms that lead to chemo- and radio-resistance underpin treatment failure. Insights into the DNA repair mechanisms that permit resistance to chemoradiotherapy in GBM may help improve patient responses to currently available therapies.
URI: http://hdl.handle.net/11434/295
URL: http://www.sciencedirect.com/science/article/pii/S0967586814005670
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/25444993
ISSN: 0967-5868
Journal Title: Journal of Clinical Neuroscience
Type: Journal Article
Affiliated Organisations: Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia
Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia.
Appears in Collections:Cancer Services
Neurosciences
Epworth Prostate Centre

Files in This Item:
There are no files associated with this item.


Items in EKB are protected by copyright, with all rights reserved, unless otherwise indicated.