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dc.contributor.authorO'Sullivan, Richarden
dc.contributor.otherTeichtahl, Andrewen
dc.contributor.otherUrquhart, Donnaen
dc.contributor.otherWang, Yuanyuanen
dc.contributor.otherWluka, Anitaen
dc.contributor.otherWijethilake, Pushpikaen
dc.contributor.otherCicuttini, Flaviaen
dc.identifier.citationSpine J. 2015 Jul 1;15(7):1593-601en
dc.description.abstractLow back pain and disability are major public health problems and may be related to paraspinal muscle abnormalities, such as a reduction in muscle size and muscle fat content. The aim of this study was to examine the associations between paraspinal muscle size and fat content with lumbar spine symptoms and structure. This was a community-based magnetic resonance imaging (MRI) cohort study. A total of 72 adults not selected on the basis of low back pain were included in the study. The outcomes measured were lumbar modic change and intervertebral disc height. Pain intensity and disability were measured from the Chronic Pain Grade Questionnaire at the time of MRI. The cross-sectional area (CSA) and amount of fat in multifidus and erector spinae (high percentage defined by >50% of muscle) were measured, and their association with outcome was assessed. Muscle CSA was not associated with low back pain/disability or structure. High percentage of fat in multifidus was associated with an increased risk of high-intensity pain/disability (odds ratio [OR], 12.6; 95% confidence interval [CI], 2.0–78.3; p=.007) and modic change (OR, 4.3; 95% CI, 1.1–17.3; p=.04). High fat replacement of erector spinae was associated with reduced intervertebral disc height (β=−0.9 mm; 95% CI, −1.4 to −0.3; p=.002) and modic change (OR, 4.9; 95% CI, 1.1–21.9; p=.04). Paraspinal fat infiltration, but not muscle CSA, was associated with high-intensity pain/disability and structural abnormalities in the lumbar spine. Although cause and effect cannot be determined from this cross-sectional study, longitudinal data will help to determine whether disabling low back pain and structural abnormalities of the spine are a cause or result of fat replacement of paraspinal muscles.en
dc.subjectIntervertebral Discen
dc.subjectLow Back Painen
dc.subjectParaspinal Muscleen
dc.subjectMRI Department, Healthcare Imaging Services, Epworth HealthCare, Victoria, Australiaen
dc.titleFat infiltration of paraspinal muscles is associated with low back pain, disability, and structural abnormalities in community-based adults.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Spine Journalen
dc.description.affiliatesDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Prahran, Victoria, Australiaen
dc.description.affiliatesBaker IDI Heart and Diabetes Institute, Prahran, Victoria, Australiaen
dc.type.studyortrialCohort Studyen
Appears in Collections:Diagnostic Services
Pain Management

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