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Title: Molecular drivers of breast implant-associated anaplastic large cell lymphoma.
Epworth Authors: Prince, Miles
Other Authors: Blombery, Piers
Thompson, Ella
Keywords: Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)
T-Cell Lymphoproliferative Disorder
Genomic Characterization
Molecular Abnormalities
ALK-Negative Systemic Anaplastic Large Cell Lymphoma (sALCL)
Rare Lymphoma Subtype
Epworth Centre for Immunotherapies and Snowdome Laboratories
Molecular Oncology and Cancer Immunology
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: May-2019
Publisher: Lippincott Williams & Wilkins
Citation: Plastic and reconstructive surgery 143.3S (2019): 59S-64S.
Abstract: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell lymphoproliferative disorder occurring in patients with breast implants. Genomic characterization performed in BIA-ALCL to date has demonstrated qualitatively similar molecular abnormalities to those seen in its more common counterpart [ALK-negative systemic anaplastic large cell lymphoma (sALCL)] including JAK/STAT activation and MYC/TP53 dysregulation. Despite these observed similarities at the molecular level, the outcomes of sALCL and BIA-ALCL are markedly different with sALCL typically associated with an aggressive course and inferior outcomes compared with BIA-ALCL. This review describes the findings of high-throughput sequencing and other genomic characterization to date in BIA-ALCL and the insights these studies have given into the molecular drivers of this rare lymphoma subtype.
DOI: 10.1097/PRS.0000000000005570
PubMed URL:
ISSN: 0032-1052
Journal Title: Plastic and Reconstructive Surgery
Type: Journal Article
Affiliated Organisations: Department of Pathology, Peter MacCalllum Cancer Centre
Sir Peter MacCallum Department of Oncology
University of Melbourne
Type of Clinical Study or Trial: Clinical Trial
Appears in Collections:Cancer Services

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