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Title: The epidemiology of breast implant-associated anaplastic large cell lymphoma in Australia and New Zealand confirms the highest risk for grade 4 surface breast implants.
Epworth Authors: Prince, Miles
Other Authors: Magnusson, Mark
Beath, Kenneth
Cooter, Rodney
Locke, Michelle
Elder, Elisabeth
Deva, Anand
Keywords: Anaplastic Large Cell Lymphoma (ALCL)
Non-Hodgkin Lymphoma (NHL)
Grade 4 Surface Breast Implants
Breast Implant-Associated (BIA)
Implant-Specific Risk
Polyurethane-Coated Silicone Gel Breast Implants
Epworth Centre for Immunotherapies and Snowdome Laboratories
Risk Assessment
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Molecular Oncology and Cancer Immunology
Issue Date: May-2019
Publisher: Lippincott Williams & Wilkins
Citation: Plastic and Reconstructive Surgery, 143(5), 1285–1292.
Abstract: Background: The epidemiology and implant-specific risk for breast implant-associated (BIA) anaplastic large cell lymphoma (ALCL) has been previously reported for Australia and New Zealand. The authors now present updated data and risk assessment since their last report. Methods: New cases in Australia and New Zealand were identified and analyzed. Updated sales data from three leading breast implant manufacturers (i.e., Mentor, Allergan, and Silimed) were secured to estimate implant-specific risk. Results: A total of 26 new cases of BIA-ALCL were diagnosed between January of 2017 and April of 2018, increasing the total number of confirmed cases in Australia and New Zealand to 81. This represents a 47 percent increase in the number of reported cases over this period. The mean age and time to development remain unchanged. The implant-specific risk has increased for Silimed polyurethane (23.4 times higher) compared with Biocell, which has remained relatively static (16.5 times higher) compared with Siltex implants. Conclusions: The number of confirmed cases of BIA-ALCL in Australia and New Zealand continues to rise. The implant-specific risk has now changed to reflect a strong link to implant surface area/roughness as a major association with this cancer.
DOI: 10.1097/PRS.0000000000005500
PubMed URL:
ISSN: 0032-1052
Journal Title: Plastic and Reconstructive Surgery
Type: Journal Article
Affiliated Organisations: Griffith University
Australian Joint BIA-ALCL Task Force
Macquarie University
Monash University
Australian Breast Device Registry
New Zealand Association of Plastic Surgeons
Sir Peter MacCallum Cancer Center and Department of Oncology
University of Melbourne
Westmead Breast Cancer Institute (BCI)
Breast Surgeons in Australia & New Zealand
Integrated Specialist Healthcare Education and Research Foundation
Type of Clinical Study or Trial: Clinical Trial
Appears in Collections:Cancer Services

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