Please use this identifier to cite or link to this item:
Title: Future directions in advanced penile cancer - mechanisms of carcinogenesis and a search for targeted therapy.
Epworth Authors: Lawrentschuk, Nathan
Heriot, Alexander
Other Authors: Teh, Jiasian
O'Connor, Ellen
O'Brein, Jonathon
Lim, Wei Mou
Taylor, Michael
Ramsay, Robert
Keywords: Immunotherapy
Penile Cancer
Solid Tumor
Squamous Cell Carcinoma
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Urology and Vascular Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Oct-2020
Publisher: Future Medicine
Citation: Future Oncol . 2020 Oct;16(29):2357-2369
Abstract: Penile squamous cell carcinoma (SCC) is a rare and aggressive urological malignancy. Advanced penile SCC requires multimodal management, including surgery and systemic therapy. Given its rarity, there have been few substantial advances in our understanding of the molecular and genomic drivers of penile SCC, especially for patients with relapsed or advanced disease. In this review, we discuss the molecular and genomic landscape of penile SCC, clinical trials in progress and implications for novel therapeutic targets. Future work should focus on preclinical models to provide a platform for investigation and validation of new molecular pathways for testing of therapeutics.
DOI: 10.2217/fon-2020-0434
PubMed URL:
ISSN: 1744-8301
Journal Title: Future Oncology
Type: Journal Article
Affiliated Organisations: Division of Cancer Surgery, Peter MacCallum Centre, Melbourne, Victoria, Australia.
University of Melbourne, Department of Surgery, Austin Hospital, Melbourne, Victoria, Australia.
Department of Surgery, University of Melbourne & Royal Melbourne Hospital, Department of Urology, Melbourne, Victoria, Australia.
Sir Peter MacCallum Dept. of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Type of Clinical Study or Trial: Review
Appears in Collections:UroRenal, Vascular

Files in This Item:
There are no files associated with this item.

Items in Epworth are protected by copyright, with all rights reserved, unless otherwise indicated.