Please use this identifier to cite or link to this item:
|Title:||Role of haematopoietic stem cell transplantation in peripheral T cell lymphoma.|
|Other Authors:||van der Weyden, Carrie|
|Keywords:||Peripheral T-cell Lymphomas|
Haematopoietic Stem Cell Transplantation
Bone Marrow Transplant
Autologous Stem Cell Transplantation
Allogeneic Stem Cell Transplantation
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
|Citation:||Cancers 2020, 12(11), 3125|
|Abstract:||Peripheral T-cell lymphomas (PTCLs) are distinct pathological entities with clinical advancements lagging behind their B-cell lymphoma counterpart. Frequently aggressive in their clinical behaviour, clinicians are constantly challenged with low complete remission rates, early relapses and failure to achieve long-term responses despite aggressive first-line chemotherapy, resulting in poor overall survival in the majority of patients. There is currently no consensus regarding the optimal therapy for PTCL and treatment approaches are mainly derived from prospective phase II studies, registry data and retrospective studies. Despite its biological heterogeneity, a less than satisfactory "one-size-fits-all" approach has been adopted to date. Although its role remains controversial, for many years, haematopoietic stem cell transplantation has been adopted by clinicians with the aim of overcoming poor outcomes by consolidating responses. In this review, we aim to define the role of both autologous and allogeneic stem cell transplantation in PTCL in both frontline and salvage settings, especially in the context of recent advancements in this field.|
|Affiliated Organisations:||Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.|
Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria 3000, Australia.
Royal Melbourne Hospital, Melbourne, Victoria 3052, Australia.
|Type of Clinical Study or Trial:||Review|
|Appears in Collections:||Cancer Services|
Items in Epworth are protected by copyright, with all rights reserved, unless otherwise indicated.