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Title: Role of haematopoietic stem cell transplantation in peripheral T cell lymphoma.
Authors: Abeyakoon, Chathuri
Harrop, Sean
Yannakou, Costas
Prince, Miles
Other Authors: van der Weyden, Carrie
Khot, Amit
Dickinson, Michael
Keywords: Peripheral T-cell Lymphomas
Haematopoietic Stem Cell Transplantation
Bone Marrow Transplant
Autologous Stem Cell Transplantation
Allogeneic Stem Cell Transplantation
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Oct-2020
Publisher: MDPI
Citation: Cancers 2020, 12(11), 3125
Abstract: Peripheral T-cell lymphomas (PTCLs) are distinct pathological entities with clinical advancements lagging behind their B-cell lymphoma counterpart. Frequently aggressive in their clinical behaviour, clinicians are constantly challenged with low complete remission rates, early relapses and failure to achieve long-term responses despite aggressive first-line chemotherapy, resulting in poor overall survival in the majority of patients. There is currently no consensus regarding the optimal therapy for PTCL and treatment approaches are mainly derived from prospective phase II studies, registry data and retrospective studies. Despite its biological heterogeneity, a less than satisfactory "one-size-fits-all" approach has been adopted to date. Although its role remains controversial, for many years, haematopoietic stem cell transplantation has been adopted by clinicians with the aim of overcoming poor outcomes by consolidating responses. In this review, we aim to define the role of both autologous and allogeneic stem cell transplantation in PTCL in both frontline and salvage settings, especially in the context of recent advancements in this field.
PubMed URL:
ISSN: 2072-6694;
Journal Title: Cancers
Type: Journal Article
Affiliated Organisations: Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria 3000, Australia.
Royal Melbourne Hospital, Melbourne, Victoria 3052, Australia.
Type of Clinical Study or Trial: Review
Appears in Collections:Cancer Services

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