Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/184
Title: Bone geometry of the hip is associated with obesity and early structural damage - a 3.0 T magnetic resonance imaging study of community-based adults.
Epworth Authors: O'Sullivan, Richard
Other Authors: Teichtahl, Andrew
Wang, Yuanyuan
Smith, Sam
Wluka, Anita
Zhu, Michael
Urquhart, Donna
Giles, Graham
Cicuttini, Flavia
Keywords: Hip Osteoarthritis
Obesity
Bony Geometry
Structural Abnormalities
Cartilage Defects
Bone Marrow Lesions
Healthcare Imaging, Epworth Hospital, Victoria, Australia
Issue Date: Apr-2015
Citation: Arthritis Res Ther. 2015 Apr 30;17:112
Abstract: The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abnormalities, such as cartilage defects and bone marrow lesions. One hundred and forty one older adults with no diagnosed hip osteoarthritis had weight and body mass index measured between 1990 and 1994 and again in 2009 to 2010. Acetabular depth and lateral centre edge angle, both measures of acetabular over-coverage, as well as femoral head cartilage volume, cartilage defects and bone marrow lesions were assessed with 3.0 T magnetic resonance imaging performed in 2009 to 2010. Current body mass index, weight and weight gain were associated with increased acetabular depth and lateral centre edge angle (all P ≤ 0.01). For every 1 mm increase in acetabular depth, femoral head cartilage volume reduced by 59 mm(3) (95% confidence interval (CI) 20 mm(3) to 98 mm(3), P < 0.01). Greater acetabular depth was associated with an increased risk of cartilage defects (odds ratio (OR) 1.22, 95% CI 1.03 to 1.44, P = 0.02) and bone marrow lesions (OR 1.29, 95% CI 1.01 to 1.64, P = 0.04) in the central region of the femoral head. Lateral centre edge angle was not associated with hip structure. Obesity is associated with acetabular over-coverage. Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions. Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.
URI: http://hdl.handle.net/11434/184
DOI: doi: 10.1186/s13075-015-0631-4
PubMed URL: http://www.ncbi.nlm.nih.gov/pubmed/25925369
ISSN: 1478-6354
Journal Title: Arthritis and Research Therapy
Type: Journal Article
Affiliated Organisations: Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Baker IDI Heart and Diabetes Institute, Commercial Road, Melbourne, VIC, 3004
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, 3053
Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Australia.
Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, 3004
Type of Clinical Study or Trial: Cohort Study
Appears in Collections:Musculoskeletal

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