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dc.contributor.authorFitzgerald, Paul-
dc.contributor.otherChen, Leo-
dc.contributor.otherRichardson, K.-
dc.contributor.otherDaskalakis, Zafiris-
dc.contributor.otherHoy, Kate-
dc.identifier.citationBrain Stimul. 2019 Aug 22. pii: S1935-861X(19)30359-6en_US
dc.description.abstractINTRODUCTION: Accelerated or intensive forms of repetitive transcranial magnetic stimulation (rTMS) are increasingly being explored for their potential to produce more efficient and rapid treatment benefits in major depressive disorder (MDD). However, accelerated or intensive protocols using standard forms of rTMS are still quite time-consuming to apply. Theta burst stimulation (TBS) is a novel form of magnetic stimulation with the potential to produce similar anti-depressant effects but in a much abbreviated period of time. The aim of this study was to investigate the comparative efficacy of an intensive TBS protocol compared to standard rTMS treatment. METHODS: 74 outpatients (36 female, mean age 44.36 ± 12.1 years) with MDD received either intensive TBS (3 intermittent TBS treatments per day for 3 days in week 1, 3 treatments a day for 2 days in week 2, and 3 treatments in 1 day in week 3 and in week 4, or standard rTMS (5 daily sessions per week for 4 weeks). Patients were assessed weekly throughout the treatment course, and at 4 weeks after treatment end. RESULTS: There were no significant differences in the degree of reduction in depressive symptoms, the rate of reduction in depressive symptoms, remission or response rates (response rates = 27.8% for intensive group, 26.3% for the standard group, p > 0.05 for all analyses) between the intensive TBS and standard rTMS treatment groups. However, the overall response and remission rates were limited in both groups. There was no difference in rates of side effects, no serious adverse events and no alterations in cognitive performance. CONCLUSION: Intensively applied TBS appears to have similar efficacy to standard rTMS when these were applied as delivered in this study but does not produce more rapid clinical benefits. The overall response rates in both groups in this study were limited, most likely by the total doses provided in both study arms.en_US
dc.subjectRepetitive Transcranial Magnetic Stimulationen_US
dc.subjectMajor Depressive Disorderen_US
dc.subjectTheta Burst Stimulationen_US
dc.subjectPatient Assessmenten_US
dc.subjectDepressive Symptomsen_US
dc.subjectResponse Ratesen_US
dc.subjectEpworth Centre for Innovation in Mental Health, The Epworth Clinic, Camberwell, Victoria, Australia.en_US
dc.subjectRehabilitation, Mental Health and Chronic Pain Clinical Institute, Epworth HealthCare, Victoria, Australia.en_US
dc.titleA pilot investigation of an intensive theta burst stimulation protocol for patients with treatment resistant depression.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBrain Stimulationen_US
dc.description.affiliatesMonash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Victoria, Australiaen_US
dc.description.affiliatesCentre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canadaen_US
dc.type.studyortrialPilot Studyen_US
Appears in Collections:Mental Health

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