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Title: Anticipating and managing the cutaneous side effects of epidermal growth factor receptor inhibitors.
Epworth Authors: Sinclair, Rodney
Keywords: EGF receptor inhibitor
Multinational Association Of Supportive Care In Cancer - MASCC
Drug-induced rash
Epidermal Growth Factor - adverse effects
Side Effects
Epidermal Growth Factor
Oncology, Medical
Clinical Oncology
Medical Oncology
Preventive therapy
Preventive measures
Skin Diseases
Dermatologic Agents
Skin Manifestations
Disease Management
Chair of Dermatology, Epworth HealthCare, Victoria, Australia
Head & Neck Clinical Institute, Epworth HealthCare, Victoria, Australia
Issue Date: Mar-2014
Citation: Volume 10, Issue Supplement S1, pages 11–17, March 2014
Abstract: Aims: Epidermal growth factor receptor inhibitor (EGFRi) therapy for tumor suppression produces significant cutaneous toxicity that may necessitate dose reduction or treatment cessation. This manuscript aims to describe the skin toxicity associated with these agents and equip oncologists with the tools to best manage these patients. Methods: A literature review of skin toxicity associated with EGFRi was conducted by a clinical dermatologist experienced in the management of these patients and a management strategy developed for EGFRi skin toxicity. Results: The sequence of development of EGFRi cutaneous toxicity is predictable. Many skin side effects can be ameliorated by prophylactic therapy. Management of established skin toxicity is complex and needs to be continued throughout the period of EGFRi drug treatment. Conclusion: Early referral to a dermatologist experienced in the management of these patients is recommended.
Description: Special Issue: Tailored Therapies – A Focus on Colorectal Cancer Proceedings from the Merck Serono Symposium, 22nd–23rd February 2013, Canberra, ACT, Australia. Publication of this supplement has been supported through an independent educational grant from Merck Serono Australia Pty Ltd.
DOI: 10.1111/ajco.12160
PubMed URL:
ISSN: 1743-7563
Journal Title: Asia Pacific Journal of Clinical Oncology
Type: Journal Article
Affiliated Organisations: The University of Melbourne, Melbourne, Victoria, Australia
St Vincent's Hospital, Melbourne, Victoria, Australia
Type of Clinical Study or Trial: Review
Appears in Collections:Cancer Services
Head & Neck

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