Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/1367
Title: Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging.
Epworth Authors: Kovalenko, Sergey
Kopsidas, George
Kelso, Joanne
Linnane, Anthony
Other Authors: Rosenfeldt, Franklin
Keywords: Aging
Genetics
DNA Damage
DNA, Mitochondrial
Electron Transport Complex IV
Metabolism
Mitochondria
Mitochondria, Heart
Mitochondria, Liver
Mitochondria, Muscle
DNA Mutation
Organ Specificity
Reactive Oxygen Species
ROS
mtDNA
mtDNA Rearrangements
Cytochrome Oxidase
COX
Centre for Molecular Biology and Medicine, Epworth Medical Centre, Richmond, Victoria, Australia.
Issue Date: Nov-1998
Publisher: New York Academy of Sciences
Citation: Ann N Y Acad Sci. 1998 Nov 20;854:171-81
Abstract: Mitochondria, according to the free radical theory of aging, are the major source of reactive oxygen species (ROS). The results, presented in this paper, question the role of reactive oxygen species in contributing significantly to the extent of mitochondrial bioenergy degradation of the tissues, which can be correlated with mtDNA rearrangements. We report here that mtDNA rearrangements, including deletions and duplications, in tissues from human aged subjects, occur in levels ranging from very low in liver, to considerable in cardiac muscle, to almost total in skeletal muscle. The extent of mtDNA rearrangements is correlated at both the individual tissue and cell level with cytochrome oxidase (COX) activity as the exemplifier of cellular bioenergy capacity. Thus, the ROS proposal in its simplest form as it affects mtDNA and mitochondrial electron transport system is not supported by the available data.
URI: http://hdl.handle.net/11434/1367
DOI: 10.1111/j.1749-6632.1998.tb09900.x
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/9928428
ISSN: 1749-6632
Journal Title: Annals of the New York Academy of Sciences
Type: Journal Article
Affiliated Organisations: Cardiac Research Unit, Baker Institute, Melbourne, Victoria, Australia
Type of Clinical Study or Trial: Review
Appears in Collections:Pre-Clinical

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