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|Title:||Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging.|
|Epworth Authors:||Kovalenko, Sergey|
|Other Authors:||Rosenfeldt, Franklin|
Electron Transport Complex IV
Reactive Oxygen Species
Centre for Molecular Biology and Medicine, Epworth Medical Centre, Richmond, Victoria, Australia.
|Publisher:||New York Academy of Sciences|
|Citation:||Ann N Y Acad Sci. 1998 Nov 20;854:171-81|
|Abstract:||Mitochondria, according to the free radical theory of aging, are the major source of reactive oxygen species (ROS). The results, presented in this paper, question the role of reactive oxygen species in contributing significantly to the extent of mitochondrial bioenergy degradation of the tissues, which can be correlated with mtDNA rearrangements. We report here that mtDNA rearrangements, including deletions and duplications, in tissues from human aged subjects, occur in levels ranging from very low in liver, to considerable in cardiac muscle, to almost total in skeletal muscle. The extent of mtDNA rearrangements is correlated at both the individual tissue and cell level with cytochrome oxidase (COX) activity as the exemplifier of cellular bioenergy capacity. Thus, the ROS proposal in its simplest form as it affects mtDNA and mitochondrial electron transport system is not supported by the available data.|
|Journal Title:||Annals of the New York Academy of Sciences|
|Affiliated Organisations:||Cardiac Research Unit, Baker Institute, Melbourne, Victoria, Australia|
|Type of Clinical Study or Trial:||Review|
|Appears in Collections:||Pre-Clinical|
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