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Title: Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone.
Authors: Sinclair, R.D.
Keywords: Hair loss
Oral Antihypertensives
Hair Growth
Female Pattern Hair Loss
Hair Loss
Head and Neck Clinical Institute, Epworth HealthCare, Melbourne, Victoria, Australia
Issue Date: Jan-2018
Publisher: Blackwell
Citation: Int J Dermatol. 2018 Jan;57(1):104-109
Abstract: BACKGROUND: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. OBJECTIVE: To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. METHODS: Women newly diagnosed with a Sinclair stage 2-5 PHL were scored for hair shedding and hair density before and after 12 months of treatment with oral minoxidil 0.25 mg and spironolactone 25 mg. RESULTS: A total of 100 women were included in this observational pilot study. Mean age was 48.44 years (range 18-80). Mean hair loss severity at baseline was Sinclair 2.79 (range 2-5). Mean hair shedding score at baseline was 4.82. Mean duration of diagnosis was 6.5 years (range 0.5-30). Mean reduction in hair loss severity score was 0.85 at 6 months and 1.3 at 12 months. Mean reduction in hair shedding score was 2.3 at 6 months and 2.6 at 12 months. Mean change in blood pressure was -4.52 mmHg systolic and -6.48 mmHg diastolic. Side effects were seen in eight women but were generally mild. No patients developed hyperkalemia or any other blood test abnormality. Six of these women continued treatment, and two women who developed urticaria discontinued treatment. LIMITATIONS: Prospective, uncontrolled, open-label observational study. DISCUSSION: Once daily capsules containing minoxidil 0.25 mg and spironolactone 25 mg appear to be safe and effective in the treatment of FPHL. Placebo-controlled studies to investigate this further are warranted.
PubMed URL:
ISSN: 0011-9059
Journal Title: International Journal of Dermatology
Type: Journal Article
Affiliated Organisations: Sinclair Dermatology Clinical Trial Centre, East Melbourne, VIC, Australia
Type of Clinical Study or Trial: Observational Study
Appears in Collections:Dermatology

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