Please use this identifier to cite or link to this item:
|Title:||A clinical database to assess action levels and tolerances for the ongoing use of Mobius3D.|
|Epworth Authors:||Jolly, David|
Clinical Decision Making
Epworth Radiation Oncology Research Centre, Epworth HealthCare, Melbourne, VIC, Australia.
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
|Citation:||J Appl Clin Med Phys. 2017 Jan;18(1):59-65|
|Abstract:||In radiation therapy, calculation of dose within the patient contains inherent uncertainties, inaccuracies, limitations, and the potential for random error. Thus, point dose-independent verification of such calculations is a well-established process, with published data to support the setting of both action levels and tolerances. Mobius3D takes this process one step further with a full independent calculation of patient dose and comparisons of clinical parameters such as mean target dose and voxel-by-voxel gamma analysis. There is currently no published data to directly inform tolerance levels for such parameters, and therefore this work presents a database of 1000 Mobius3D results to fill this gap. The data are tested for normality using a normal probability plot and found to fit this distribution for three sub groups of data; Eclipse, iPlan and the treatment site Lung. The mean (μ) and standard deviation (σ) of these sub groups is used to set action levels and tolerances at μ ± 2σ and μ ± 3σ, respectively. A global (3%, 3 mm) gamma tolerance is set at 88.5%. The mean target dose tolerance for Eclipse data is the narrowest at ± 3%, whilst iPlan and Lung have a range of -5.0 to 2.2% and -1.8 to 5.0%, respectively. With these limits in place, future results failing the action level or tolerance will fall within the worst 5% and 1% of historical results and an informed decision can be made regarding remedial action prior to treatment.|
|Journal Title:||Journal of Applied Clinical Medical Physics|
|Type of Clinical Study or Trial:||Validation Study|
|Appears in Collections:||Cancer Services|
Files in This Item:
|Jolly_et_al-2017-Journal_of_Applied_Clinical_Medical_Physics.pdf||651.35 kB||Adobe PDF||View/Open|
Items in EKB are protected by copyright, with all rights reserved, unless otherwise indicated.