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Title: Bing-Neel syndrome - Bilateral cavernous sinus lymphoma causing visual failure.
Epworth Authors: Griffiths, James
Other Authors: Pham, Chengde
Cam, Anthony
Hun, Martin
Keywords: Bing-Neel Syndrome
Cavernous Sinus
Central Nervous System
Waldenstrom Macroglobulinaemia
Vision Loss
Bilateral Cavernous Sinus
Lymphoplasmacytic Lymphoma
Treatment Outcomes
Neurosurgical Intervention
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Melbourne Haematology, Epworth HealthCare, Victoria, Australia
Issue Date: Jul-2017
Publisher: Elsevier
Citation: J Clin Neurosci. 2017 Jul 29. pii: S0967-5868(16)31423-0
Abstract: We report the case of a 68-year-old male with right eye vision loss secondary to a compressive optic neuropathy from Waldenstrom macroglobulinaemia relapse in both cavernous sinuses. Central nervous system involvement is extremely uncommon in lymphoplasmacytic lymphoma. Known as Bing-Neel syndrome, this has not been previously reported to present simultaneously in bilateral cavernous sinuses. We discuss the pathophysiology, diagnostic and neuroradiological features of Bing-Neel syndrome. In this case, there was marked clinical and radiological response to chemotherapy. As outcomes following treatment for Waldenstrom macroglobulinaemia improve, greater awareness of its less common manifestations becomes important. Neurosurgical intervention may be indicated to obtain histological diagnosis or decompress critical structures.
DOI: 10.1016/j.jocn.2017.07.010
PubMed URL:
ISSN: 0967-5868
Journal Title: Journal of Clinical Neuroscience
Type: Journal Article
Affiliated Organisations: Department of Neurosurgery, Level 1, Old Baker Building, The Alfred Hospital, 55 Commercial Rd, Melbourne, Victoria 3004, Australia.
Department of Radiology, Level 1, Phillip Block, The Alfred Hospital, 55 Commercial Rd, Melbourne, Victoria 3004, Australia.
Type of Clinical Study or Trial: Case Reports
Appears in Collections:Cancer Services

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