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|Title:||The impact of disability in survivors of critical illness.|
|Other Authors:||Hodgson, Carol|
|Keywords:||Intensive Care Unit|
Quality of Life
Post Intensive Care Syndrome
Limitation in Activites
World Health Organisation's International Classification of Functioning
World Health Organisation's Disability Assessment Schedule 2.0
Critical Care Clincial Institute, Epworth HealthCare, Victoria, Australia
Monash-Epworth Rehabilitation Research Centre, Epworth HealthCare, Melbourne, Australia
|Citation:||Intensive Care Med. 2017 Jul;43(7):992-1001|
|Abstract:||PURPOSE: To use the World Health Organisation's International Classification of Functioning to measure disability following critical illness using patient-reported outcomes. METHODS: A prospective, multicentre cohort study conducted in five metropolitan intensive care units (ICU). Participants were adults who had been admitted to the ICU, received more than 24 h of mechanical ventilation and survived to hospital discharge. The primary outcome was measurement of disability using the World Health Organisation's Disability Assessment Schedule 2.0. The secondary outcomes included the limitation of activities and changes to health-related quality of life comparing survivors with and without disability at 6 months after ICU. RESULTS: We followed 262 patients to 6 months, with a mean age of 59 ± 16 years, and of whom 175 (67%) were men. Moderate or severe disability was reported in 65 of 262 (25%). Predictors of disability included a history of anxiety/depression [odds ratio (OR) 1.65 (95% confidence interval (CI) 1.22, 2.23), P = 0.001]; being separated or divorced [OR 2.87 (CI 1.35, 6.08), P = 0.006]; increased duration of mechanical ventilation [OR 1.04 (CI 1.01, 1.08), P = 0.03 per day]; and not being discharged to home from the acute hospital [OR 1.96 (CI 1.01, 3.70) P = 0.04]. Moderate or severe disability at 6 months was associated with limitation in activities, e.g. not returning to work or studies due to health (P < 0.002), and reduced health-related quality of life (P < 0.001). CONCLUSION: Disability measured using patient-reported outcomes was prevalent at 6 months after critical illness in survivors and was associated with reduced health-related quality of life. Predictors of moderate or severe disability included a prior history of anxiety or depression, separation or divorce and a longer duration of mechanical ventilation.|
|Journal Title:||Intensive Care Medicine|
|Affiliated Organisations:||Australian and New Zealand Intensive Care Research Centre, Melbourne, Australia.|
The Alfred Hospital, Melbourne, Australia.
Monash University, Melbourne, Australia.
Monash Partners Academic Health Science Centre, Prahran, Australia.
Cabrini Hospital, Melbourne, Australia.
Austin Health, Melbourne, Australia.
Deakin University, Geelong, Australia.
University of Michigan, Michigan, USA.
Monash Medical Centre, Melbourne, Australia.
|Type of Clinical Study or Trial:||Prospective Cohort Study|
|Appears in Collections:||Critical Care|
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