Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/1121
Title: Impact of apolipoprotein gene on cognitive impairment and recovery after traumatic brain injury.
Epworth Authors: Ponsford, Jennie
Other Authors: Ng, K. T.
Bailey, Karen
Rudzki, Dion
Keywords: Traumatic Brain Injury
TBI
Brain Injuries
Genetics
Attention
Physiology
Complications
Genetics
Psychology
Cognition Disorders
Diagnosis
Physiopathology
DNA Mutational Analysis
Disability Evaluation
Apolipoprotein E4
Gene Dosage
Gene Frequency
Genetic Predisposition to Disease
Genetics
Genetic Testing
Genotype
Glasgow Coma Scale
Executive Function
Functional Outcome
Memory
Physiology
Memory Disorders
Physiopathology
Neuropsychological Tests
Recovery of Function
Thinking
Department of Psychology, Epworth Rehabilitation Centre, Epworth, Richmond VIC 3121, Australia.
Monash- Epworth Rehabilitation Research Centre, Melbourne, VIC. Australia.
Issue Date: Feb-2007
Publisher: Wolters Kluwer
Citation: Neurology. 2007 Feb 20;68(8):619-20.
Abstract: The presence of the ε4 allele may have a negative influence on response to injury and recovery in patients with traumatic brain injury (TBI).1,2 However, no study to date has included an uninjured control group to examine whether the influence of the ε4 allele might be independent of TBI. In this study, we investigated whether presence of the ε4 allele in patients with TBI results in greater impairments of memory, attention, executive function, and functional outcome 3, 6, and 12 months postinjury, and in slower recovery, than in patients without the ε4 allele and uninjured controls. Methods. Following ethics approval and informed consent, 120 patients with moderate–severe TBI, aged 16 to 64 years, with no history of previous neurologic or psychiatric disorder were assessed 3, 6, and 12 months postinjury. They comprised 69.2% men, with mean Glasgow Coma Scale score (GCS) 8.24 (SD = 4.17, range = 3 to 15), mean post-traumatic amnesia (PTA) 26.14 days (SD = 28.64, range = <1 to 135), mean age 32.66 years (SD 13.38, range = 17 to 64), mean education 12.48 years (SD = 2.38, range = …
URI: http://hdl.handle.net/11434/1121
DOI: 10.1212/01.wnl.0000254609.04330.9d
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/17310037
ISSN: 0028-3878
Journal Title: Neurology
Type: Journal Article
Affiliated Organisations: Monash University, Melbourne, Australia.
Type of Clinical Study or Trial: Comparative Study
Appears in Collections:Mental Health
Neurosciences
Rehabilitation

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