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|Title:||Cellular redox regulation and prooxidant signaling systems: a new perspective on the free radical theory of aging.|
|Epworth Authors:||Linnane, Anthony|
Oxido-reduction Nutritional Supplements
Cellular Redox Poise Regulation
Hydrogen Peroxide Formation
Subcellular Redox State
Alpha Lipoic Acid
Mammalian Aging Process
Multisystem Stochastic Process
Centre for Molecular Biology and Medicine, Epworth Medical Centre, Richmond, Victoria, Australia.
|Citation:||Ann N Y Acad Sci. 2006 May;1067:47-55|
|Abstract:||The overarching role of coenzyme Q10 in gene regulation, bioenergy formation, cellular redox poise regulation, and hydrogen peroxide formation is presented. Coenzyme Q10 has a central role acting as a prooxidant in the generation of H2O2. Contrary to the dogma that superoxide and H2O2 formation are highly deleterious to cell survival this premise is rejected. Data are discussed that continuous superoxide and hydrogen peroxide formation are essential for normal cell function and that they play a major role in subcellular redox state modulation. It is the prooxidant activity of the so-called antioxidants that may be responsible for previously claimed benefits for high doses of oxido-reduction nutritional supplements such as alpha lipoic acid and coenzyme Q10. Oxygen-free radical formation is essential for the biological function and is not a direct causation of the mammalian aging process; aging is a multisystem stochastic process.|
|Journal Title:||Annals of the New York Academy of Sciences|
|Type of Clinical Study or Trial:||Review|
|Appears in Collections:||Pre-Clinical|
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