Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/1085
Title: Cellular redox regulation and prooxidant signaling systems: a new perspective on the free radical theory of aging.
Epworth Authors: Linnane, Anthony
Eastwood, Hayden
Keywords: Aging
Animals
Antioxidants
Oxido-reduction Nutritional Supplements
Cell Cycle
Free Radicals
Cellular Redox Poise Regulation
Hydrogen Peroxide Formation
Metabolism
Models, Biological
Oxidation-Reduction
Signal Transduction
Superoxides
Pharmacology
Coenzyme Q10
Ubiquinone
Subcellular Redox State
Gene Regulation
Alpha Lipoic Acid
Mammalian Aging Process
Multisystem Stochastic Process
Bioenergy Formation
Centre for Molecular Biology and Medicine, Epworth Medical Centre, Richmond, Victoria, Australia.
Issue Date: May-2006
Publisher: Wiley
Citation: Ann N Y Acad Sci. 2006 May;1067:47-55
Abstract: The overarching role of coenzyme Q10 in gene regulation, bioenergy formation, cellular redox poise regulation, and hydrogen peroxide formation is presented. Coenzyme Q10 has a central role acting as a prooxidant in the generation of H2O2. Contrary to the dogma that superoxide and H2O2 formation are highly deleterious to cell survival this premise is rejected. Data are discussed that continuous superoxide and hydrogen peroxide formation are essential for normal cell function and that they play a major role in subcellular redox state modulation. It is the prooxidant activity of the so-called antioxidants that may be responsible for previously claimed benefits for high doses of oxido-reduction nutritional supplements such as alpha lipoic acid and coenzyme Q10. Oxygen-free radical formation is essential for the biological function and is not a direct causation of the mammalian aging process; aging is a multisystem stochastic process.
URI: http://hdl.handle.net/11434/1085
DOI: 10.1196/annals.1354.008
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/16803970
ISSN: 1749-6632
Journal Title: Annals of the New York Academy of Sciences
Type: Journal Article
Type of Clinical Study or Trial: Review
Appears in Collections:Pre-Clinical
Internal Medicine

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