Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/1020
Title: C-choline PET is superior to T2-weighted MRI for localising malignant intraprostatic lesions for guiding prostate cancer focal therapies.
Epworth Authors: Chang, Joe
Joon, D. L.
Davis, Ian
Lee, Sze Ting
Hiew, Chee Yan
Esler, Stephen
Gong, Sylvia
Wada, Morikatsu
Clouston, David
O'Sullivan, Richard
Goh, Yin
Bolton, Damien
Scott, Andrew
Other Authors: Khoo, Vincent
Keywords: C-choline
CHOL
Positron Emission Tomography
PET
T2-Weighted
T2W
Magnetic Resonance Imaging
MRI
Intraprostatic Lesions
IPLs
Focal Therapy
Radical Prostatectomy
Dice Similarity Coefficient
DSC
CHOL PET
T2W MRI
Ludwig Institute for Cancer Research, Epworth Healthcare, Victoria, Australia
Cancer Services Clinical Institute, Epworth Healthcare, Victoria, Australia
Epworth Prostate Cancer Research Centre, Epworth HealthCare, Victoria, Australia
Issue Date: Apr-2014
Citation: Internal Medicine Journal, Volume 44, Issue Supplement S1 (pp. 13-14).
Conference: 44th Annual Scientific Meeting of the Australian and New Zealand Society of Nuclear Medicine (ANZSNM), 25–28
Conference Location: Adelaide Convention Centre, Adelaide, Australia.
Abstract: BACKGROUND: To compare the accuracy of 11C-choline (CHOL) positron emission tomography (PET) with T2-weighted (T2W) magnetic resonance imaging (MRI) for delineating malignant intraprostatic lesions (IPLs) for focal therapies and to investigate factors predicting the accuracy of CHOL PET. METHODS: This prospective study included thirty patients who underwent CHOL PET and MRI prior to radical prostatectomy. Two observers manually delineated IPL contours for each scan, and automatic IPL contours were generated on CHOL PET based on varying proportions of the maximum standardised uptake value (SUV). IPLs identified on prostatectomy specimens defined the reference standard contours. The imaging-based contours were compared with the reference standard contours using Dice similarity coefficient (DSC), sensitivity and specificity. Factors that could potentially predict the DSC of the best contouring method were analysed using linear models. RESULTS: The best automatic contouring method, SUV60, had significantly better correlations (DSC 0.602) than the manual PET contours (DSC 0.517, P = 0.027) and the manual MRI contours (DSC 0.310, P < 0.001). The sensitivity and specificity values were 75.0% and 69.7% for SUV60; 52.0% and 86.2% for PET manual contouring; and 23.8% and 95.4% for MRI manual contouring. The tumour volume and transition zone pattern could independently predict the accuracy of CHOL PET. CONCLUSIONS: CHOL PET is superior to T2W MRI; and SUV60 automatic contouring is superior to manual contouring for delineating IPLs for focal therapies. The transition zone pattern is a new classification that may predict for how well CHOL PET delineates IPLs.
URI: http://hdl.handle.net/11434/1020
DOI: 10.1111/imj.12418
Type: Conference Poster
Affiliated Organisations: Royal Marsden Hospital, London, UK.
Dept Urologic Surgery, Austin Health, Victoria, Australia
Monash University, Australia
Monash Health, Australia
Royal Marsden Hospital, London, UK
Type of Clinical Study or Trial: Prospective Study
Appears in Collections:Epworth Prostate Centre
Cancer Services
UroRenal, Vascular
Diagnostic Services

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