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|Title:||Vitamin D deficiency and early breast cancer: an Australian experience.|
|Epworth Authors:||Bergin, Alice|
de Boer, Richard
|Keywords:||Vitamin D Deficiency|
Cancer Services Clinical Institute, Epworth HealthCare, Victoria, Australia
Epworth Freemasons Hospital, East Melbourne, VIC, Australia
|Citation:||Asia Pac J Clin Oncol. 2016 Nov; Volume 12, Issue Supplement S5 (pp 136).|
|Conference:||COSA's 43 and ANZBCTG's 38 Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care. 15–17 November|
|Conference Location:||Gold Coast Convention and Exhibition Centre, Queensland|
|Abstract:||AIM: Adequate levels of vitamin D are important for optimal bone health. Australian women with early breast cancer are frequently vitamin D deficient and are exposed to additional risk factors for osteoporosis. To gauge the burden of vitamin D deficiency, this study was designed to assess serum 25(OH)-D levels at two time-points: at commencement and completion of adjuvant systemic chemotherapy. METHODS: Serum 25(OH)-D levels were measured in patients over two time periods: 2009–2011 (cohort 1) and 2012–2016 (cohort 2). Cohort 1 included 253 women and assessed 25(OH)-D levels at chemotherapy completion. Changes in serum 25(OH)-D levels were followed in a subgroup of patients (n = 63, subgroup A) at 3 and at 12 months. Cohort 2 included 267 patients and assessed 25(OH)-D levels during chemotherapy. Baseline 25(OH)-D levels were measured within weeks of surgery, and a subgroup (n = 102, subgroup B) agreed to check levels at chemotherapy completion and 3 months later. RESULTS: In cohort 1, 53% (of 253 women) were vitamin D deficient (< 50 nmol/L) after systemic chemotherapy and in cohort 2, 44% (of 267) had deficient serum 25OH-D levels prior to chemotherapy. In the majority, the deficiency was mild. In subgroup A, there was a considerable improvement in serum 25(OH)-D levels, from 63% deficient. In subgroup B, all 102 women had normal vitamin D levels prior to chemotherapy (>50 nmol/L). After chemotherapy, 51% had become deficient, but following replacement, only 6% were deficient 3 months later. CONCLUSION: Vitamin D deficiency is common in Australian women with early breast cancer. Assessment and replacement of vitamin D should become part of routine management in this population.|
|Type of Clinical Study or Trial:||Cohort Study|
|Appears in Collections:||Cancer Services|
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